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Faster-Acting Insulins - Medscape

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Faster-Acting Insulins
Program Overview
Impact of Postprandial Hyperglycemia
Major Mechanisms Linking Elevated PPG to Diabetes Complications
Recommended Targets for PPG
Insulin Replacement Therapy Aimsto Recreate the Normal Blood Insulin Profile
PK Profiles of Insulin Replacement Therapies
Faster-Acting Insulin:Approaching a More Exact Physiologic Insulin Profile
Effects of Hormone Signaling on Hepatic Glucose Metabolism
Faster Aspart: A New Formulation of Insulin Aspart
Faster Aspart vs Insulin Aspart via SC Injection:PK/PD Comparisons*
PK/PD Differences of Faster Aspart With CSII Are Even More Pronounced Than With SC Injections
PD Differences Between Faster Aspart and Insulin Aspart of Similar Magnitude Compared With Differences Between Insulin Aspart and RHI
Onset®Program for Faster Aspart
Onset® 1:Study Design
Onset® 1:Mean HbA1cChange From Baseline
Onset® 1:PPG Increment at Week 26
Onset® 1:Safety
Timing of Administration of Faster Aspart
Timing of Meal Insulin and Its Relation to Adherence to Therapy in T1DM
Practical Recommendations Regarding Timing of Administration
Other Faster-Acting Insulins in Development
Onset, Offset, and Overall Exposure of Faster Aspart vs Insulin Aspart in CSII
Onset® 4:A Trial Evaluating Compatibility and Safety of Faster Aspart and Insulin Aspart With an External CSII System in Adults With T1DM
Patients With T1DM Who May Be Candidates for Faster Aspart
24-Year-Old Woman With T1DM
Onset® 2:Study Design
Onset® 2*:Mean Change in HbA1c Over Time
Onset® 2:PPG Increment (Meal Test) at Week 26
Onset®2:Treatment-Emergent Hypoglycemia
Other Faster-Acting Insulins in Development (cont)
Patients With T2DM Who May Be Candidates for Faster Aspart
58-Year-Old Man With T2DM for 8 Years
58-Year-Old Man With T2DM for 8 Years(cont)
58-Year-Old Man With T2DM for 8 Years(cont)
58-Year-Old Man With T2DM for 8 Years (cont)
58-Year-Old Man With T2DM for 8 Years (cont)
60-Year-Old Woman With T2DM for 15 Years
60-Year-Old Woman With T2DM for 15 Years (cont)
60-Year-Old Woman With T2DM for 15 Years (cont)
60-Year-Old Woman With T2DM for 15 Years (cont)
60-Year-Old Woman With T2DM for 15 Years (cont)
Conclusions
Conclusions (cont)

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Faster-Acting Insulins - Medscape